pentobarbital will reduce the level or influence of gefitinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism.
pentobarbital will lessen the level or outcome of lonafarnib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Lonafarnib is usually a delicate CYP3A4 substrate. Coadministration with potent or reasonable CYP3A4 inducers is contraindicated.
pentobarbital will reduce the extent or influence of midazolam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.
pentobarbital will minimize the level or impact of lumefantrine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Coadministration with strong CYP3A4 inducers can result in decreased serum concentrations and loss of antimalarial efficacy
Repeatedly monitor essential signs throughout sedation and recovery time period if coadministered. Meticulously titrate remimazolam dose if administered with opioid analgesics and/or sedative/hypnotics.
Insignificant (1)pentobarbital will minimize the extent or result of paclitaxel protein bound by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Small/Significance Unknown.
pentobarbital will lower the level or result of estropipate by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.
pentobarbital will reduce the level or effect of dasatinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on.
Selections concerning the timing of any get more info elective procedures requiring anesthesia really should acquire into consideration the many benefits of the process weighed versus the opportunity hazards
Comment: Barbiturates may perhaps maximize adverse effects, which include respiratory depression, made by harmful doses of TCAs. With therapeutic doses of TCAs, barbiturates improve metabolism and reduce blood concentrations of TCAs.
pentobarbital decreases levels of elvitegravir/cobicistat/emtricitabine/tenofovir DF by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Could bring on lack of virologic response and achievable resistance.
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pentobarbital will minimize the level or outcome of nimodipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Importance Unknown.
pentobarbital will minimize the extent or effect of nitrendipine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Importance Mysterious.