pentobarbital will reduce the level or influence of gefitinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will lessen the level or outcome of lonafarnib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Lonafarnib is usually a delicate CYP3A4 substrate. Coadministration with potent or reasonab